Highest-synergy pair of genes. Genes RBP1 and EEF1B2 in combination appear to predict prostate cancer in ways that cannot be attributed to the additive individual contributions of the genes (see P values in Table 2). (A) Scatter plot for the two genes. Red and green dots represent 52 cancerous and 50 healthy samples, respectively. The red dot indicated by the arrow represents sample T39, which appears to have been mislabelled as cancerous, a possibility also supported by scatter plots involving totally different genes (Figure 6). (B) Dendrogram for the corresponding two-dimensional scatter plot indicating a partition with good classification performance.
Watkinson et al. BMC Systems Biology 2008 2:10 doi:10.1186/1752-0509-2-10