EGFR and GPCR systems behave like over-damped mechanical oscillators. (A) Schematic of a mass-spring-damper system. The system comprises of a mass connected to a wall via a spring with spring constant k (= mωn2) and a damper with damping constant B (= 2mζωn). The mass m is set in motion in response to the external force F, and the displacement x is a function of ωn the natural frequency and ζ the damping ratio. (B&C) Dependence of ωn (red line) and ζ (blue line) of the EGFR system on D (B) and of the GPCR system on kds (C).
Shankaran et al. BMC Systems Biology 2007 1:48 doi:10.1186/1752-0509-1-48