Characteristics of the EGFR frequency response. The response of the EGFR system was computed for a sinusoidal input of wavelength 200 min and a dimensionless peak value A* of 0.001. (A) The dimensionless EGFR response is plotted for various downregulation values, D. (B) In order to illustrate the time delay between the input and output waveforms, we computed the normalized response Cn * by dividing the dimensionless response C* with the maximum value reached in the chosen time range. This normalized response is plotted as a function of time for the D values indicated. The input is denoted by a black dotted line. (C) The time delay between the input and output waveforms was computed using each of the maxima in the response and is plotted as a function of the peak number.
Shankaran et al. BMC Systems Biology 2007 1:48 doi:10.1186/1752-0509-1-48