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Open Access Highly Accessed Research article

Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

Harish Shankaran1, H Steven Wiley2 and Haluk Resat1*

Author Affiliations

1 Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland WA 99352, USA.

2 Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA 99352, USA.

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BMC Systems Biology 2007, 1:48  doi:10.1186/1752-0509-1-48

Published: 9 November 2007

Additional files

Additional File 1:

Supplementary Methods. Detailed descriptions of numerical and analytical solution methodology and rate constants employed in the mathematical model.

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