Schematic view of the multicellular model. View of the different layers of the mammalian skin, and how they are represented in the multicellular model. Connections through the Wnt pathway are represented in red and connections through the Notch pathway are represented in blue. The level of Notch receptor of each cell is fixed, and the corresponding values are indicated in the cells. Both the dermis and the cornified layer (composed of dead cells) are not represented in the model. The required result for each cell in the case of wild type simulation is indicated below the cell. Cells of the basal layer are proliferating, while cells of the suprabasal layers are differentiated.
Schaub et al. BMC Systems Biology 2007 1:4 doi:10.1186/1752-0509-1-4