Yeast gene co-expression module networks: the relationship between fundamental network concepts. This figure demonstrates Observation 3 and equation (14). The figures on the left (right) hand side depict network concepts from the weighted (unweighted) network. Each point is a gene colored by its module assignment. The red line has intercept 0 and slope 1. Figures A) and B) illustrate the relationship between the mean clustering coefficient (short horizonal line) and (1 + Heterogeneity2)2 * Density (equation (11)). Figure C) and D) illustrates the relationship between the topological overlap with the hub node and (Density + Centralization) * (1 + Heterogeneity2) (equation (14)).
Dong and Horvath BMC Systems Biology 2007 1:24 doi:10.1186/1752-0509-1-24