Figure 3.

Overview of the MSGR. A. The genes mapped through the BTP table, denoted "Ortholog Map," are supplied as queries to an organism-specific GeneRecommender [7] search (gray ovals). The search orderings of each organism (dashed arrows) and of all ancestral search nodes that are parents in the phylogenetic merge tree (solid arrows) are reported. The five ancestral merge nodes are Ecdysozoan (Ecdy), Animal (Anim), Opisthokont (Opis), Eukaryote (Euk), and Cellular (Cell). H.sap, Homo sapiens; D.mel, Drosophila melanogaster; C.ele,Caenorhabditis elegans;S.cer, Saccharomyces cerevisiae; A.tha, Arabidopsis thaliana; H.pyl, Helicobacter pylori. B. Illustration of the merging of search orderings using a human cell-cycle pathway as the query. Nodes in the phylogenetic merge tree are shown as gray ovals. GR, GeneRecommender. Boxes represent search orderings output as lists of genes. Numbers in parentheses are the ranks of the genes in the search ordering.