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Open Access Highly Accessed Case report

Disseminated intravascular coagulation in a dog naturally infected by Leishmania (Leishmania) chagasi from Rio de Janeiro – Brazil

Carla O Honse1*, Fabiano B Figueiredo1, Nayro X de Alencar2, Maria de Fátima Madeira3, Isabella DF Gremião1 and Tânia MP Schubach1

Author Affiliations

1 Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Av. Brasil, 4365, Manguinhos, Rio de Janeiro 21045-900, Brasil

2 Laboratório Clínico Veterinário, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal Fluminense, Rua Vital Brasil Filho, 64, Niterói, 24230-340, Rio de Janeiro, Brasil

3 Laboratório de Vigilância em Leishmaniose, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Av. Brasil, 4365, Manguinhos, 21045-900, Rio de Janeiro, Brasil

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BMC Veterinary Research 2013, 9:43  doi:10.1186/1746-6148-9-43

Published: 5 March 2013

Abstract

Background

Disseminated intravascular coagulation (DIC) is an acquired disorder characterized by the activation of intravascular coagulation and excessive fibrin formation. It always occurs in association with other clinical conditions, including parasitic diseases. DIC has been described as a unusual complication in human and canine visceral leishmaniasis.

Case presentation

DIC was found in a seven-year-old male mongrel dog naturally infected by Leishmania (Leishmania) chagasi. Haemostasis parameters demonstrated changes in primary and secondary haemostasis and fibrinolysis.

Conclusion

DIC is a unusual condition described in canine visceral leishmaniasis and it seems to be associated with several immunological and pathological mechanisms involved in the disease.

Keywords:
Disseminated intravascular coagulation; Dog; Visceral leishmaniasis