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Open Access Highly Accessed Research article

The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis

David Bennett1*, Peter David Eckersall2, Mary Waterston2, Veronica Marchetti3, Alessandra Rota3, Eilidh McCulloch4 and Silvia Sbrana3

Author Affiliations

1 School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH, Scotland

2 Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH, Scotland

3 Department of Veterinary Clinics, Faculty of Veterinary Medicine, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, Pisa 56010, Italy

4 ReactivLab Ltd, Garscube Estate, Bearsden Rd, Glasgow G61 1QH, UK

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BMC Veterinary Research 2013, 9:42  doi:10.1186/1746-6148-9-42

Published: 1 March 2013

Abstract

Background

Robenacoxib is a novel and highly selective inhibitor of COX-2 in dogs and cats and because of its acidic nature is regarded as being tissue-selective. Thirty four dogs with stifle osteoarthritis secondary to failure of the cranial cruciate ligament were recruited into this study. Lameness, radiographic features, synovial cytology and C-reactive protein concentrations in serum and synovial fluid were assessed before and 28 days after commencing a course of Robenacoxib at a dose of 1 mg/kg SID.

Results

There was a significant reduction in the lameness score (P < 0.01) and an increase in the radiographic score (P < 0.05) between pre- and post-treatment assessments. There was no difference between pre- (median 1.49 mg/l; Q1-Q3 0.56-4.24 mg/L) and post – (1.10 mg/L; 0.31-1.78 mg/L) treatment serum C-reactive protein levels although synovial fluid levels were significantly reduced (pre- : 0.44 mg/L; 0.23-1.62 mg/L; post- : 0.17 mg/L; 0.05-0.49 mg/L) (P < 0.05). There was no correlation between C-reactive protein concentrations in serum and matched synovial fluid samples.

Conclusions

Robenacoxib proved effective in reducing lameness in dogs with failure of the cranial cruciate ligament and osteoarthritis of the stifle joint. The drug also reduced levels of C-reactive protein in the synovial fluid taken from the affected stifle joint. Robenacoxib appears to reduce articular inflammation as assessed by C-reactive protein which supports the concept that Robenacoxib is a tissue-selective non-steroidal anti-inflammatory drug.

Keywords:
Stifle; Osteoarthritis; Cruciate disease; C-reactive protein; Synovial fluid; Robenacoxib