Table 3

Prognostic factors significantly associated with overall survival
Variable Univariate Multivariable*
Hazard ratio 95% CI P Hazard ratio 95% CI P
Tumour size
< 3 cm Referent
≥ 3 cm 2.79 1.16-6.68 0.022 NS
Mode of growth
Expansive Referent
Invasive 4.63 1.08-19.85 0.039 NS
Histological type
Complex carcinomas Referent
Simple carcinomas 2.75 0.62-12.17 NS
Others 6.48 1.34-31.22 0.020 NS
Histological grade
I + II Referent
III 2.52 1.09-5.82 0.031 NS
MIB1 L.I. (%)
< 40 Referent Referent
≥ 40 4.60 1.79-11.85 0.002 4.06 1.56-10.58 0.004
uPA (%)
< 10 Referent
≥ 10 5.28 1.23-22.60 0.025 NS
MMP-9 (%)
< 50 Referent Referent
≥ 50 4.21 1.76-1.09 0.001 3.67 1.52-8.89 0.004

* Cox proportional hazard model: forward stepwise method – likelihood ratio.

NS – not significant.

Santos et al.

Santos et al. BMC Veterinary Research 2013 9:1   doi:10.1186/1746-6148-9-1

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