Table 5

Comparison of pharmacokinetic parameters of meloxicam in domestic animal species, IV administration
IV administration (mean values)
Parameter Llamas* Cattle* Goats* Horses** Sheep* Camels*
(Units) (present study) [18] [19] [20] [21] [22]
AUCINF(hr*μg/mL) 43.96 82.34 29.74 NR 49.26 346.7
Cl or ClT(mL/min/kg) 0.190 0.1 0.298 0.34 0.169 0.032
C0(μg/mL) 6.16 5.93 3.12 NR 4.96 NR
T ½ λz or T ½β(hr) 17.4 20.35 10.9 8.54 14.0 40.2
Vss (L/kg) 0.235 0.171 0.245 0.12 178.7 0.093
Dose (mg/kg) 0.5 0.5 0.5 0.6 0.5 0.6

NR = not reported.

* Non-compartmental pharmacokinetic analysis.

** Compartmental pharmacokinetic analysis.

AUCINF = area under the curve extrapolated to infinity; Cl = plasma clearance; ClT = total body clearance; C0 = Concentration extrapolated to time 0 using log-linear regression of the first two time points; T ½ λz, T ½ β = terminal half-life; Vss = volume of distribution at steady state.

Kreuder et al.

Kreuder et al. BMC Veterinary Research 2012 8:85   doi:10.1186/1746-6148-8-85

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