Table 4

Comparison of pharmacokinetic parameters of meloxicam in domestic animal species, PO administration
PO administration (mean values)
Parameter Llamas* Cattle* Goats* Horses** Sheep*
(Units) (present study) [18] [19] [20] [21]
AUCINF(hr*μg/mL) 68.35 164.46 23.24 NR 75.09
Cl/F (mL/min/kg) 0.248 0.1 NR NR 0.220
CMAX(μg/mL) 1.31 3.10 0.736 1.73 1.715
TMAX(hr) 21.4 11.64 15 3.4 19.0
T ½ λz (hr) 22.7 27.54 11.8 NR 15.4
Vz/F (L/kg) 0.487 0.242 NR NR 0.293
Dose (mg/kg) 1.0 1.0 0.5 0.6 0.99
F (%) 76.0 100.0 79.0 95.6 72.0

NR = not reported.

* Non-compartmental pharmacokinetic analysis.

** Compartmental pharmacokinetic analysis.

AUCINF = area under the curve extrapolated to infinity; Cl/F = Cl per fraction of the dose absorbed; CMAX = maximum plasma concentration; TMAX; = time to CMAX; T ½ λz, T ½β = terminal half-life; Vz/F = Vz per fraction of the dose absorbed; F = fraction of the dose absorbed.

Kreuder et al.

Kreuder et al. BMC Veterinary Research 2012 8:85   doi:10.1186/1746-6148-8-85

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