## Table 3 |
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Comparison of pharmacokinetic parameters of common NSAIDS in llamas |
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IV dosages (mean values) |
PO dosages (mean values) |
|||||||

Parameter (Units) |
Meloxicam (present study) |
Phenylbutazone[8] |
Ketoprofen[7]* |
Flunixin meglumine[6] |
Meloxicam (present study) |
Phenylbutazone[8] |
||

S |
R |
Sum |
||||||

AUC (hr*μg/mL) |
43.96 | 80.1 | 168.9 | 176.4 | 345.3 | 49.0 | 68.35 | 60.8 |

Cl (mL/min/kg) |
0.190 | 1.11 | 0.22 | 0.21 | 0.43 | 0.78 | N/A | N/A |

T_{MAX}(hr) |
N/A | N/A | N/A | N/A | 21.4 | 4.37 | ||

T ½ λz(hr) |
17.4 | 2.03 | 5.49 | 5.41 | 5.45 | 1.47 | 22.7 | 7.09 |

Vss(L/kg) |
0.235 | 0.155 | 0.100 | 0.095 | 0.195 | 0.030 | N/A | N/A |

Dose (mg/kg) |
0.50 | 5.0 | 2.2 | 2.2 | 4.4 | 2.2 | 1.0 | 5 |

F (%) |
N/A | N/A | N/A | N/A | 76.0 | 69.9 |

* For the ketoprofen study, a racemic mixture of S and R enantomers were administered to each animal. PK values from each enantomer as well as the sum (or in the case of half –life, average) of both are reported here.

AUC = area under the curve extrapolated to infinity; Cl = plasma clearance; T_{MAX;} = time to C_{MAX;} T ½ λz = terminal half-life; Vss = volume of distribution at steady state; F = fraction
of the dose absorbed.

Kreuder * et al.*

Kreuder * et al.* *BMC Veterinary Research* 2012 **8**:85 doi:10.1186/1746-6148-8-85