Table 3 |
||||||||
| Comparison of pharmacokinetic parameters of common NSAIDS in llamas | ||||||||
| IV dosages (mean values) | PO dosages (mean values) | |||||||
| Parameter (Units) | Meloxicam (present study) | Phenylbutazone[8] | Ketoprofen[7]* | Flunixin meglumine[6] | Meloxicam (present study) | Phenylbutazone[8] | ||
| S | R | Sum | ||||||
| AUC (hr*μg/mL) | 43.96 | 80.1 | 168.9 | 176.4 | 345.3 | 49.0 | 68.35 | 60.8 |
| Cl (mL/min/kg) | 0.190 | 1.11 | 0.22 | 0.21 | 0.43 | 0.78 | N/A | N/A |
| TMAX(hr) | N/A | N/A | N/A | N/A | 21.4 | 4.37 | ||
| T ½ λz(hr) | 17.4 | 2.03 | 5.49 | 5.41 | 5.45 | 1.47 | 22.7 | 7.09 |
| Vss(L/kg) | 0.235 | 0.155 | 0.100 | 0.095 | 0.195 | 0.030 | N/A | N/A |
| Dose (mg/kg) | 0.50 | 5.0 | 2.2 | 2.2 | 4.4 | 2.2 | 1.0 | 5 |
| F (%) | N/A | N/A | N/A | N/A | 76.0 | 69.9 | ||
* For the ketoprofen study, a racemic mixture of S and R enantomers were administered to each animal. PK values from each enantomer as well as the sum (or in the case of half –life, average) of both are reported here.
AUC = area under the curve extrapolated to infinity; Cl = plasma clearance; TMAX; = time to CMAX; T ½ λz = terminal half-life; Vss = volume of distribution at steady state; F = fraction of the dose absorbed.
Kreuder et al. BMC Veterinary Research 2012 8:85 doi:10.1186/1746-6148-8-85
