Table 3

Comparison of pharmacokinetic parameters of common NSAIDS in llamas
IV dosages (mean values) PO dosages (mean values)
Parameter (Units) Meloxicam (present study) Phenylbutazone[8] Ketoprofen[7]* Flunixin meglumine[6] Meloxicam (present study) Phenylbutazone[8]
S R Sum
AUC (hr*μg/mL) 43.96 80.1 168.9 176.4 345.3 49.0 68.35 60.8
Cl (mL/min/kg) 0.190 1.11 0.22 0.21 0.43 0.78 N/A N/A
TMAX(hr) N/A N/A N/A N/A 21.4 4.37
T ½ λz(hr) 17.4 2.03 5.49 5.41 5.45 1.47 22.7 7.09
Vss(L/kg) 0.235 0.155 0.100 0.095 0.195 0.030 N/A N/A
Dose (mg/kg) 0.50 5.0 2.2 2.2 4.4 2.2 1.0 5
F (%) N/A N/A N/A N/A 76.0 69.9

* For the ketoprofen study, a racemic mixture of S and R enantomers were administered to each animal. PK values from each enantomer as well as the sum (or in the case of half –life, average) of both are reported here.

AUC = area under the curve extrapolated to infinity; Cl = plasma clearance; TMAX; = time to CMAX; T ½ λz = terminal half-life; Vss = volume of distribution at steady state; F = fraction of the dose absorbed.

Kreuder et al.

Kreuder et al. BMC Veterinary Research 2012 8:85   doi:10.1186/1746-6148-8-85

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