Table 5

Responses of pigs to vaccination with O/HN/CHA/93 and rM-HN vaccines and O/Tibet/CHA/99 challenge
Vaccinea Pig no. VNT titer versus O/Tibet/CHA/99b Response to challenge with O/Tibet/CHA/99 Vaccinea Pig no. VNT titer versus O/Tibet/CHA/99b Response to challenge with O/Tibet/CHA/99
Lesionsc 3ABCd Lesionsc 3ABCd
O/HN/CHA/93 101 1.6 - - rM-HN 601 2.1 - -
102 1.7 - - 202 1.6 - -
103 2.0 - - 203 1.6 - -
104 1.7 - - 204 2.0 - -
105 1.5 - - 205 1.8 - -
106 2.1 - - 206 2.1 - -
107 1.8 - - 207 1.7 - -
108 2.0 - - 208 1.9 - -
109 1.5 - - 209 1.8 - -
110 1.9 - - 210 2.0 - -
111 2.1 - - 211 1.8 - +
112 1.9 - - 212 2.0 - -
113 1.8 - - 213 1.6 - -
114 1.6 - - 214 2.1 - -
115 2.1 - - 215 1.7 - -
116 1.7 - - 216 2.0 - -
Control 117 <1.0 ++ + Control 217 <1.0 ++ +
118 <1.0 ++ + 218 <1.0 ++ +

a BEI-inactivated virus.

b Day 28 virus neutralization titer (expressed as the log10 of the reciprocal antibody dilution required for 50% neutralization of 100 TCID50 virus) values represent the means from two repeat tests.

c Scoring of clinical signs: -, no visible lesions, +, localized gross lesions; + +, generalized lesions.

d Presence of antibodies to the nonstructural protein 3ABC in sera collected 14 days post-challenge, determined by the commercially available 3ABC-I-ELISA kit. Samples were considered positive if the cutoff value ≥0.2.

Li et al.

Li et al. BMC Veterinary Research 2012 8:57   doi:10.1186/1746-6148-8-57

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