Table 2

Main studies on the inhibition of skin wheal response in dogs - key findings
Subjects Intradermal challenge Drug Administration route Treatment time Wheal inhibition vs baseline Ref
Healthy Beagle dogs Anti-canine IgE Corticosteroids (prednisolone) Oral Twice daily for 3 days No effect [38]
Dogs with pruritic dermatitis Histamine (5 different dilutions) Corticosteroids (hydrocortisone 1%) Topical (conditioner) Twice weekly for 6 weeks No effect [39]
Healthy Beagle dogs Histamine Corticosteroids (betamethasone) Topical (otic preparation) Twice daily for 2 weeks 5.9% [40]
Healthy Beagle dogs D. farinae Corticosteroids (betamethasone) Topical (otic preparation) Twice daily for 2 weeks 9% [40]
Healthy Beagle dogs Cynodon dactylon Corticosteroids (betamethasone) Topical (otic preparation) Twice daily for 2 weeks 9.8% [40]
Healthy Beagle dogs Anti-canine IgE Corticosteroids (hydrocortisone 1%) Topical (conditioner) 3 days 14% (*) [41]
Healthy dogs Anti-canine IgE (different dilutions) Corticosteroids (triamcinolone) Topical (solution) 7 days 24-45% (§) depending on the stimulus concentration [42]
Healthy mixed breed dogs D. farinae Corticosteroids (prednisone) Oral 7 days 41% [43]
Atopic Maltese-beagle cross-breed dogs Anti-canine IgE Corticosteroids (hydrocortisone aceponate) Topical (spray) 7 days 72% [44]
Healthy mixed breed dogs D. farinae Antihistamines (cetrizine) Oral 14 days 49% [43]
Spontaneously Ascaris hypersensitive Beagle dogs A. suum Antihistamines (rupatadine) Oral Single pre-treatment dose 35, 67 and 84% (#) [27]
Spontaneously Ascaris hypersensitive Beagle dogs A. suum Antihistamines (loratadine) Oral Single pre-treatment dose 34, 61 and 66% (#) [27]
Healthy Beagle dogs PAF Antihistamines (rupatadine) Oral Single pre-treatment dose 30% to 45% (¥) [47]
Healthy Beagle dogs Histamine Antihistamines (rupatadine) Oral Single pre-treatment dose 50% to 80% (¥) [47]
Healthy Beagle dogs Histamine Antihistamines (cetrizine, loratadine, rupatadine, levocabastine) Oral Single pre-treatment dose 70% to 80% (**) [48]
Healthy Beagle dogs Histamine Antihistamines (cetrizine, loratadine, rupatadine, levocabastine) Oral Single pre-treatment dose 70% to 80% (**) [48]

(*) versus placebo group;

(§) versus vehicle-treated side;

(#) peak activity at 0.1, 1 and 10 mg/Kg respectively, 2 to 4 hrs after administration;

(¥) peak activity, 4 h after administration, depending on the dose;

(**) peak activity, 4 h after administration, depending on the compound and the dose.

Cerrato et al.

Cerrato et al. BMC Veterinary Research 2012 8:230   doi:10.1186/1746-6148-8-230

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