Figure 3.

SEM images of biofilms formed on canine orthopaedic bone screws treated with addition of clarithromycin. (A) Showing minimal MRSP biofilm production at 4 h (B) showing increased EPS (extracellular polymeric substance) and morphological changes characteristic to biofilms at 12 h (C) firm attachment of MRSP biofilm, further increase of EPS and clumping of cells at 24 h (D) MRSP biofilm growth concentrated to specific areas on the screw head.

DiCicco et al. BMC Veterinary Research 2012 8:225   doi:10.1186/1746-6148-8-225
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