Table 4

Amplification of experimental and natural strains of ovine prion diseases
Strain Genotype Substrate
VRQ ARQ AFRQ*
SSBP1 (n = 1) VRQ + - ND
Dawson (n = 1) VRQ + - ND
MRI Suffolk (n = 3) ARQ −/−/− +/−/− ND
Atypical scrapie (n = 7) ARQ (n = 5) or ARR (n = 2) −/−/−/−/−/− −/−/−/−/−/− −/−/−/−/−/−

n = number of animals tested. Samples were tested in duplicate in separate assays *AFRQ/AFRQ substrate where F represents amino acid at position 141. The AFRQ/AFRQ genotype is more commonly associated with atypical scrapie [19]. ND = not done. +/− symbols show the amplification outcome for each animal.

Thorne et al.

Thorne et al. BMC Veterinary Research 2012 8:223   doi:10.1186/1746-6148-8-223

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