Luminal B phenotype: concordant and discordant cases. Line 1: Luminal B concordant case with PR+ and c-erbB-2+ (1A, 1B) in theprimary neoplasia and PR+, cerbB-2+, CK14+ (1C, 1D, 1E) in the lymph node metastases. Line 2: Discordant case showing luminal B phenotype PR+, c-erbB-2+ (2A, 2B) in the primary tumor becoming c-erbB-2 overexpressing phenotype in the lymph node PR–, c-erbB-2+, CK5/6+ (2C, 2D, 2E). Line 3: Discordant case with luminal B phenotype ER+, c-erbB-2+ (3A, 3B) in the mammary tumor and progression to basal-like phenotype ER–, c-erbB-2–, CK 14+ (3D, 3E, 3F) in the respective nodal metastasis. Line 4: Discordant case presenting in the primary mammary carcinoma luminal A phenotype ER+, c-erbB-2– (4A, 4B) and normal-like phenotype PR–, cerbB-2–, p63– (4D, 4E, 4F) in the lymph node. 400x.
Beha et al. BMC Veterinary Research 2012 8:219 doi:10.1186/1746-6148-8-219