Figure 1.

Luminal A phenotype: concordant and discordant cases. Line 1: Luminal A concordant case with ER+ and c-erbB-2– (1A, 1B) in the primary tumor and ER+, cerbB-2–, CK14– (1C, 1D, 1E) in the lymph node metastases. Line 2: Discordant case with luminal A phenotype PR+, c-erbB-2– (2A, 2B) in the mammary tumor and progression to basal-like phenotype PR–, c-erbB-2–, CK14+ (2C, 2D, 2E) in the respective nodal metastasis. Line 3: Discordant case presenting in the primary mammary carcinoma luminal A phenotype ER+, c-erbB-2– (3A, 3B) and normal-like phenotype ER–, cerbB-2–, CK5/6– (200x) (3C, 3D, 3E) in the lymph node. 400x.