|Multivariable analysis showing association between congenital hereditary sensorineural deafness (CHSD) in Australian Cattle Dogs (n = 534) and sex, mask and pigmented body spots from a multilevel logistic model and an animal model|
|Variable||Multilevel logistic model*||Logistic animal model**|
|Adjusted odds ratio (95% CI)†||P-value||Adjusted odds ratio (95% CI)†||P-value|
|Male||Reference category||Reference category|
|Female||2.0 (1.0 to 3.8)||0.035||1.9 (1.1 to 3.6)||0.034|
|No||Reference category||Reference category|
|Left||0.9 (0.4 to 2.2)||0.807||0.9 (0.4 to 2.1)||0.775|
|Right||1.1 (0.5 to 2.7)||0.765||1.0 (0.4 to 2.4)||0.915|
|Bilateral||0.2 (0.1 to 0.5)||<0.001||0.2 (0.1 to 0.5)||<0.001|
|Pigmented body spot||0.023||0.052|
|None||Reference category||Reference category|
|At least one||0.3 (0.1 to 0.9)||0.038||0.4 (0.1 to 1.0)||0.050|
Sex mask and pigmented body spot were simultaneously fitted in multivariable models. The odds ratios are for having at least one deaf ear rather than normal hearing. These analyses demonstrate that these three variables were each independently associated with CHSD.
* Multilevel logistic models with dog fitted within litter within kennel of birth. Bolded P-values are overall likelihood ratio test P-values; unbolded P-values are Wald P-values for each coefficient.
** Logistic animal (‘threshold’) models using the full pedigree (ie all pedigree data that were available), with dog fitted as a random effect with a numerator relationship matrix. Bolded P-values are overall Wald P-values; unbolded P-values are Wald P-values for each coefficient.
*** Overall p-value for mask in logistic animal model not calculated.
† 95% CI indicates 95% confidence interval.
Sommerlad et al.
Sommerlad et al. BMC Veterinary Research 2012 8:202 doi:10.1186/1746-6148-8-202