Table 3

Gene ontologies of the human orthologs of differentially expressed equine plasma proteins
Spot Gene Name Expression Molecular Function KEGG Pathway
980 alpha-2-macroglobulin Up-regulated Serine-type endopeptidase inhibitor activity, growth factor binding, cytokine binding, chemokine binding Complement and coagulation cascades
980 angiotensinogen Up-regulated Serine-type endopeptidase inhibitor activity, growth factor activity, acetyltransferase activator activity, angiotensin receptor binding Renin-angiotensin system
1299 apolipoprotein A-IV Up-regulated Phospholipid binding, antioxidant activity, cholesterol transporter activity
1272 coagulation factor X Down-regulated Serine-type endopeptidase activity Complement and coagulation cascades
836 fibrinogen beta chain Down-regulated Protein binding, bridging Complement and coagulation cascades
1056, 1057, 1083 fibrinogen gamma chain Down-regulated Protein binding, bridging Complement and coagulation cascades
836 IgM Down-regulated Antigen binding
1056 IgA Down-regulated Antigen binding
819 kininogen 1 Down-regulated Pattern binding, cysteine-type endopeptidase inhibitor activity, heparin binding Complement and coagulation cascades
819 protein S, alpha (vitronectin) Down-regulated Endopeptidase inhibitor activity, calcium ion binding Complement and coagulation cascades
457 alpha-1 antitrypsin Down-regulated Serine-type endopeptidase inhibitor activity Complement and coagulation cascades
836, 980 antithrombin Down-regulated (836), Up-regulated (980) Pattern binding, serine-type endopeptidase inhibitor activity, heparin binding Complement and coagulation cascades
1083 alpha-2 antiplasmin Down-regulated Serine-type endopeptidase inhibitor activity Complement and coagulation cascades
462, 819 C1 inhibitor Down-regulated Complement binding, serine-type endopeptidase inhibitor activity Complement and coagulation cascades
457 alpha-2-HS-glycoprotein Down-regulated Cysteine-type endopeptidase inhibitor activity, protein tyrosine kinase inhibitor activity
1056, 1057, 1083 fetuin B Down-regulated Cysteine-type endopeptidase inhibitor activity
1272, 1299 similar to Complement C3 precursor Down-regulated (1272), Up-regulated (1299) Endopeptidase inhibitor activity Complement and coagulation cascades

Steelman and Chowdhary

Steelman and Chowdhary BMC Veterinary Research 2012 8:179   doi:10.1186/1746-6148-8-179

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