## Table 1 |
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Mean plasma pharmacokinetic parameters for meloxicam after IV administration at 0.5 mg/kg
bodyweight determined using a two- compartment model |
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Parameter |
Units |
Mean |
Standard error |

V_{c} |
mL/kg | 94.88 | 9.04 |

V_{2} |
mL/kg | 99.07 | 7.85 |

V_{ss} |
mL/kg | 193.94 | 10.34 |

CL | mL/h/kg | 6.64 | 0.76 |

CLD_{2} |
mL/h/kg | 225.18 | 47.43 |

T_{½α} |
hr | 0.22 | 0.087 |

T_{½β} |
hr | 21.86 | 3.03 |

AUC | hr*ug/mL | 81.02 | 10.58 |

MRT | hr | 31.24 | 4.37 |

K_{10} |
1/h | 0.075 | 0.012 |

K_{12} |
1/h | 2.70 | 0.78 |

K_{21} |
1/h | 2.20 | 0.39 |

V_{c,} - volume of the central compartment; V_{2} - volume of the peripheral compartment; V_{ss}- apparent volume of distribution at steady-state; CL - total body clearance; CLD_{2:} - distributional clearance from the central compartment to the peripheral compartment;
T_{½α} and T_{½β} half-lives for the distribution phases; AUC- area under the time-concentration curve;
MRT- mean residence time of the drug in the body; k_{12} and k_{21} - μ-rate constants for the drug’s movement between the central and peripheral compartments;
and k_{10} - elimination rate constant.

Coetzee * et al.*

Coetzee * et al.* *BMC Veterinary Research* 2012 **8**:153 doi:10.1186/1746-6148-8-153