Table 3 |
|
| Differentially expressed genes in PPC + S group involved in immune and inflammatory responses (mean fold change of PPC control group levels) | |
| Gene | Fold change ± SE |
| Inflammatory mediators and transducers | |
| Interleukin-22 | 10.35 ± 3.67 |
| Interleukin-18 | 2.66 ± 0.84 |
| Chemokine CK-1 | 4.75 ± 0.99 |
| C-C motif chemokine 19-1 | 3.73 ± 1.12 |
| Suppressor of cytokine signaling 1 | 2.68 ± 0.33 |
| C-C chemokine receptor type 9 | 2.57 ± 0.68 |
| C-C motif chemokine 21 | −1.95 ± 0.30 |
| Interleukin-6 receptor subunit alpha | 2.73 ± 0.98 |
| Interleukin-1 receptor type II | 2.07 ± 0.30 |
| Interleukin-1 receptor antagonist | 1.65 ± 0.09 |
| Arachidonate 5-lipoxygenase-activating protein | 3.49 ± 0.91 |
| Leukotriene b4 12-hydroxydehydrogenase | 2.43 ± 0.40 |
| Annexin A1 | 11.46 ± 5.46 |
| Annexin A2-A | 2.13 ± 0.20 |
| Annexin A5 | 2.39 ± 0.33 |
| TNF decoy receptor | 5.37 ± 1.26 |
| TNF receptor superfamily member 5 | 1.83 ± 0.21 |
| TNFalpha-induced protein 8-like protein 2 | 1.78 ± 0.21 |
| NF-kappa-B p100 subunit | 2.14 ± 0.07 |
| NF-kappa-B inhibitor alpha | 1.71 ± 0.03 |
| NF-kappa-B inhibitor epsilon | 1.96 ± 0.14 |
| CCAAT/enhancer binding protein beta-2 | 3.00 ± 0.98 |
| Transcription factor AP-1 | 1.67 ± 0.20 |
| Transcription factor jun-B | 2.16 ± 0.32 |
| IFN-dependent | |
| MHC class I antigen | −4.27 ± 0.95 |
| MHC class I | −5.42 ± 0.16 |
| MHC class Ia heavy chain | −3.76 ± 1.56 |
| Beta-2 microglobulin | −2.27 ± 0.52 |
| Tyrosine-protein kinase Jak1 | 2.14 ± 0.26 |
| Similar to very large inducible GTPase 1 | −5.81 ± 1.54 |
| Receptor-transporting protein 3 | −3.52 ± 0.91 |
| Gamma-interferon-inducible thiol reductase | −2.67 ± 0.65 |
| Interferon-induced protein 44 | −2.48 ± 0.39 |
| Fish virus induced TRIM protein | −2.12 ± 0.37 |
| SRK2 tyrosine kinase | −1.89 ± 0.24 |
| Galectin-3-binding protein | −1.74 ± 0.22 |
| Effectors: complement and lectins, antimicrobial proteins | |
| FBPL4 (lectin) | 7.46 ± 2.29 |
| Precerebellin-like protein (lectin) | 8.58 ± 4.27 |
| Complement factor D | 4.46 ± 1.93 |
| Complement C1q-like protein 2 | 3.34 ± 1.41 |
| Complement C1q-like protein 4 | 2.26 ± 0.59 |
| C5a anaphylatoxin chemotactic receptor | 2.34 ± 0.61 |
| Complement component C6 | 2.45 ± 0.65 |
| Properdin P factor 2 | 1.76 ± 0.17 |
| C1 inhibitor | −5.25 ± 1.31 |
| C4b-binding protein alpha chain | −1.77 ± 0.16 |
| Nattectin | 5.97 ± 2.21 |
| Cathelicidin | 7.08 ± 3.32 |
| High affinity IG epsilon receptor gamma | 3.32 ± 1.16 |
| High affinity IG gamma Fc receptor I | 1.85 ± 0.11 |
| Differentially regulated trout protein 1 | 3.39 ± 1.28 |
| C type lectin receptor A | 2.20 ± 0.48 |
| Proteases and inhibitors, T-cells | |
| E3 ubiquitin-protein ligase LINCR | 18.11 ± 1.38 |
| Matrix metalloproteinase-9 | 3.56 ± 1.34 |
| Collagenase 3 | 4.38 ± 1.74 |
| Matrix metalloproteinase | 2.97 ± 1.03 |
| E74-like factor 3 | 2.78 ± 0.31 |
| Metalloproteinase inhibitor 2 | 4.67 ± 1.44 |
| Leukocyte elastase inhibitor | 1.75 ± 0.06 |
| T-cell receptor beta chain T17T-22 | 6.73 ± 1.91 |
| T-cell immunoglobulin and mucin domain-containing 4 | 2.30 ± 0.51 |
| CD86 | 1.90 ± 0.24 |
| CTLA4-like protein | 2.04 ± 0.22 |
| Oxidative burst, protection against free radicals | |
| Myeloperoxidase | 32.43 ± 4.77 |
| Cytochrome b558 alpha-subunit | 7.06 ± 1.86 |
| Cytochrome b-245, beta polypeptide | 3.08 ± 1.12 |
| Neutrophil cytosolic factor 1 | 7.19 ± 3.88 |
| Arginase-2, mitochondrial | 14.78 ± 2.87 |
| Ornithine decarboxylase 1 | 1.76 ± 0.26 |
| Nitric oxide synthase trafficker | −1.67 ± 0.25 |
| Glutathione reductase, mitochondrial | 2.30 ± 0.34 |
| Glutathione peroxidase 4b | −2.05 ± 0.12 |
| Glutathione S-transferase alpha 3 | −2.63 ± 0.36 |
| Glutathione S-transferase kappa 1-like | −1.88 ± 0.25 |
| Glutathione S-transferase P | −2.72 ± 0.67 |
| Glutathione transferase zeta 1 isoform 1 | −1.96 ± 0.12 |
| Peroxiredoxin-4 | −1.69 ± 0.14 |
| Catalase | −2.47 ± 0.05 |
| Arrestin domain-containing protein 2 | −2.59 ± 0.13 |
| CDGSH iron sulfur domain-containing protein 1 | −2.50 ± 0.32 |
| Peptide methionine sulfoxide reductase | −1.77 ± 0.21 |
| 5-aminolevulinate synthase, nonspecific, mitochondrial | 3.54 ± 0.46 |
| Metallothionein A | −6.46 ± 0.95 |
| Heme oxygenase | −6.58 ± 1.78 |
| Heme-binding protein 2 | −2.89 ± 0.44 |
| Ferritin, middle subunit | −3.03 ± 0.26 |
| High affinity copper uptake protein 1 | −2.62 ± 0.52 |
| Copper transport protein ATOX1 | −3.41 ± 0.80 |
Kortner et al. BMC Veterinary Research 2012 8:101 doi:10.1186/1746-6148-8-101
