Table 3

Differentially expressed genes in PPC + S group involved in immune and inflammatory responses (mean fold change of PPC control group levels)
Gene Fold change ± SE
Inflammatory mediators and transducers
Interleukin-22 10.35 ± 3.67
Interleukin-18 2.66 ± 0.84
Chemokine CK-1 4.75 ± 0.99
C-C motif chemokine 19-1 3.73 ± 1.12
Suppressor of cytokine signaling 1 2.68 ± 0.33
C-C chemokine receptor type 9 2.57 ± 0.68
C-C motif chemokine 21 −1.95 ± 0.30
Interleukin-6 receptor subunit alpha 2.73 ± 0.98
Interleukin-1 receptor type II 2.07 ± 0.30
Interleukin-1 receptor antagonist 1.65 ± 0.09
Arachidonate 5-lipoxygenase-activating protein 3.49 ± 0.91
Leukotriene b4 12-hydroxydehydrogenase 2.43 ± 0.40
Annexin A1 11.46 ± 5.46
Annexin A2-A 2.13 ± 0.20
Annexin A5 2.39 ± 0.33
TNF decoy receptor 5.37 ± 1.26
TNF receptor superfamily member 5 1.83 ± 0.21
TNFalpha-induced protein 8-like protein 2 1.78 ± 0.21
NF-kappa-B p100 subunit 2.14 ± 0.07
NF-kappa-B inhibitor alpha 1.71 ± 0.03
NF-kappa-B inhibitor epsilon 1.96 ± 0.14
CCAAT/enhancer binding protein beta-2 3.00 ± 0.98
Transcription factor AP-1 1.67 ± 0.20
Transcription factor jun-B 2.16 ± 0.32
IFN-dependent
MHC class I antigen −4.27 ± 0.95
MHC class I −5.42 ± 0.16
MHC class Ia heavy chain −3.76 ± 1.56
Beta-2 microglobulin −2.27 ± 0.52
Tyrosine-protein kinase Jak1 2.14 ± 0.26
Similar to very large inducible GTPase 1 −5.81 ± 1.54
Receptor-transporting protein 3 −3.52 ± 0.91
Gamma-interferon-inducible thiol reductase −2.67 ± 0.65
Interferon-induced protein 44 −2.48 ± 0.39
Fish virus induced TRIM protein −2.12 ± 0.37
SRK2 tyrosine kinase −1.89 ± 0.24
Galectin-3-binding protein −1.74 ± 0.22
Effectors: complement and lectins, antimicrobial proteins
FBPL4 (lectin) 7.46 ± 2.29
Precerebellin-like protein (lectin) 8.58 ± 4.27
Complement factor D 4.46 ± 1.93
Complement C1q-like protein 2 3.34 ± 1.41
Complement C1q-like protein 4 2.26 ± 0.59
C5a anaphylatoxin chemotactic receptor 2.34 ± 0.61
Complement component C6 2.45 ± 0.65
Properdin P factor 2 1.76 ± 0.17
C1 inhibitor −5.25 ± 1.31
C4b-binding protein alpha chain −1.77 ± 0.16
Nattectin 5.97 ± 2.21
Cathelicidin 7.08 ± 3.32
High affinity IG epsilon receptor gamma 3.32 ± 1.16
High affinity IG gamma Fc receptor I 1.85 ± 0.11
Differentially regulated trout protein 1 3.39 ± 1.28
C type lectin receptor A 2.20 ± 0.48
Proteases and inhibitors, T-cells
E3 ubiquitin-protein ligase LINCR 18.11 ± 1.38
Matrix metalloproteinase-9 3.56 ± 1.34
Collagenase 3 4.38 ± 1.74
Matrix metalloproteinase 2.97 ± 1.03
E74-like factor 3 2.78 ± 0.31
Metalloproteinase inhibitor 2 4.67 ± 1.44
Leukocyte elastase inhibitor 1.75 ± 0.06
T-cell receptor beta chain T17T-22 6.73 ± 1.91
T-cell immunoglobulin and mucin domain-containing 4 2.30 ± 0.51
CD86 1.90 ± 0.24
CTLA4-like protein 2.04 ± 0.22
Oxidative burst, protection against free radicals
Myeloperoxidase 32.43 ± 4.77
Cytochrome b558 alpha-subunit 7.06 ± 1.86
Cytochrome b-245, beta polypeptide 3.08 ± 1.12
Neutrophil cytosolic factor 1 7.19 ± 3.88
Arginase-2, mitochondrial 14.78 ± 2.87
Ornithine decarboxylase 1 1.76 ± 0.26
Nitric oxide synthase trafficker −1.67 ± 0.25
Glutathione reductase, mitochondrial 2.30 ± 0.34
Glutathione peroxidase 4b −2.05 ± 0.12
Glutathione S-transferase alpha 3 −2.63 ± 0.36
Glutathione S-transferase kappa 1-like −1.88 ± 0.25
Glutathione S-transferase P −2.72 ± 0.67
Glutathione transferase zeta 1 isoform 1 −1.96 ± 0.12
Peroxiredoxin-4 −1.69 ± 0.14
Catalase −2.47 ± 0.05
Arrestin domain-containing protein 2 −2.59 ± 0.13
CDGSH iron sulfur domain-containing protein 1 −2.50 ± 0.32
Peptide methionine sulfoxide reductase −1.77 ± 0.21
5-aminolevulinate synthase, nonspecific, mitochondrial 3.54 ± 0.46
Metallothionein A −6.46 ± 0.95
Heme oxygenase −6.58 ± 1.78
Heme-binding protein 2 −2.89 ± 0.44
Ferritin, middle subunit −3.03 ± 0.26
High affinity copper uptake protein 1 −2.62 ± 0.52
Copper transport protein ATOX1 −3.41 ± 0.80

Kortner et al.

Kortner et al. BMC Veterinary Research 2012 8:101   doi:10.1186/1746-6148-8-101

Open Data