Table 2

Results for laboratory tests and response categories for dogs with idiopathic IMHA treated according to the AP protocol (n = 149) or the P protocol (n = 73) group at the time of the first and second return visits and relapse

Azathioprine-Prednisolone Protocol

Prednisolone Protocol


First return visit

Median

Range

n

Reference

Median

Range

n

Pb


Hematocrit (%)

0.35

0.06-0.5

93

42-57

0.36

0.12-0.47

41

0.5

Thrombocytes (x109/L)

402

8-986

88

150-400

421

20-1555

29

0.48

Reticulocytes (%)

0.9

0.1-28

87

< 2

2

0.2-6.4

34

0.027*

Osmotic red cell fragility (mOsm/L)

176

136-258

82

< 162

164

125-247

24

0.06

Time after diagnosis g (days)

25

2-83

95

17

0-141

43

0.001*

Response categorya

No. dogs

n

No. dogs

n

Pb

No responsec

3

95

1

26

Improvementd

87

95

25

26

Complete recoverye

5

95

0

26

0.92


Second return visit

Median

Range

n

Reference

Median

Range

n

Pb


Hematocrit (%)

0.4

0.11-0.54

66

42-57

0.42

0.18-0.51

24

0.38

Thrombocytes (x109/L)

278

3-834

63

150-400

339

12-636

17

0.73

Reticulocytes (%)

0.8

0.1-12

60

< 2

1

0.3-9.7

18

0.39

Osmotic red cell fragility (mOsm/L)

163

133-238

58

< 162

165

142-206

11

0.40

Time after diagnosis g (days)

77

21-399

69

56

21-171

25

0.0032*

Response categorya

No. dogs

n

No. dogs

n

Pb

No response

0

62

0

13

Improvement

42

62

12

13

Complete recovery

20

62

1

13

0.12


Relapsef

Median

Range

n

Reference

Median

Range

n

pb


Hematocrit (%)

0.28

0.06-0.44

17

42-57

0.31

0.10-0.41

5

0.96

Thrombocytes (x109/L)

132

0-382

15

150-400

327

228-426

2

0.15

Reticulocytes (%)

2.5

0.1-22

14

< 2

0.3

0.2-30.5

3

0.9

Osmotic red cell fragility (mOsm/L)

212

159-274

12

< 162

221

187-254

2

0.65

Time after diagnosisg (days)

112

32-1757

21

63

7-581

8

0.27


aNumber of dogs counted in each response category.

b P = P value

c No effect of therapy was defined as no increase in the hematocrit.

d Improvement was defined as an increase in hematocrit to < 0.36 L/L, or a hematocrit >0.36 L/L but with a positive Coombs' test or an increased osmotic red cell fragility.

e Complete recovery was defined as an increase in the hematocrit to >0.36 L/L, a negative Coombs' test, and an osmotic red cell fragility within the reference range.

f Relapse was defined as a decrease in the hematocrit after an initial improvement or complete recovery in combination with the recurrence of a positive Coombs' test or increased red cell fragility.

g The times of the first and second return visits or when a relapse occurred were retrieved from the medical record.

Piek et al. BMC Veterinary Research 2011 7:15   doi:10.1186/1746-6148-7-15

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