Table 3

Relative frequency of clinical signs expressed at the pre-cull examination compared to control cattle

Study

1

1

1

2

2

2


Groups

1 g & 100 g

1 g

100 g

4

3

2


Postmortem BSE diagnosis

Pos

Neg

Neg

Pos

Neg

Neg


Behaviour


Crush refused or entered reluctantly

↑↑↑

↑↑↑


Nervous or apprehensive in corridor

↑↑↑

↑↑

↑↑


Obstacle refused or not approached

↓↓

↓↓


Nervous entering milking parlour

---

---

---


Yawning


Kicked out during examination


Sensation


Startle repeatedly during examination

↑↑↑

↑↑↑

↑↑↑


Startle once during examination

↑↑↑


Clipboard test abnormal once

↑↑↑


Clipboard test abnormal >2

↑↑↑


Over-reactivity to sound ≥1

↑↑↑


Over-reactivity present once/2 tests

↑↑↑


Over-reactivity present >2/2 tests

↑↑↑


Over-reactivity to sound >2

↑↑


Flash test abnormal ≥1


Flash test abnormal >2


Exaggerated menace


Head tests nervous

↑↑


Stick test: kicking


Movement


Tremor

↑↑↑


Ataxia or hypermetria

↑↑↑


Groups were compared with undosed controls (study 1) or saline-inoculated controls (study 2). The BSE-positive animals dosed with 1 g and 100 g in study 1 were combined to increase the sample size.

(↑) increased frequency of sign; (↓) decreased frequency of sign compared to control cattle, with P<0.001 (three arrows), P = 0.001-0.01 (two arrows) and P>0.01 and <0.05 (one arrow). Blank cell: not significant (P>0.05) or no P-value given because of absence of this sign in both groups.

Only signs that were significantly differently displayed compared to controls are listed.

Konold et al. BMC Veterinary Research 2010 6:53   doi:10.1186/1746-6148-6-53

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