Additional file 4.


143 (BSE positive-IHC). Steer, examined prior to cull at 42 months after oral dosing with 100 g of BSE affected brainstem homogenate (study 1). This steer does not over-react to cranial nerve testing but repeatedly startles at a sudden metallic sound (recorded as "repeated over-reactivity to sound"). It appears apprehensive in the corridor, circles on the spot and startles when it is encouraged to move away from the gate by hand clapping. The histopathological diagnosis was inconclusive for BSE (minimal vacuolation in the obex) but BSE was confirmed by other postmortem tests.

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Konold et al. BMC Veterinary Research 2010 6:53   doi:10.1186/1746-6148-6-53