Phylogenetic relationship of AKR1C family members of human, mouse, cow and pig. Multiple sequence alignment was performed by ClustalW and neighbor-joining tree of full-length amino acid sequences is shown. Species is designated by a lower case letter preceding the AKR1C gene family member (h = human; b = bovine; p = porcine and m = mouse). Numbers at branches represent 1000 bootstrapped datasets and scale bar represents substitutions per site. Human genes are from the AKR1C cluster on chromosome 10p15, mouse and bovine genes are from chromosomes 13 in both species and the five pig genes on SSC10q described in this study. In general, except for AKR1CL2, paralogues within species are more related than are homologues among species.
Nonneman et al. BMC Veterinary Research 2006 2:28 doi:10.1186/1746-6148-2-28