Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA

doi:10.1186/1746-6148-1-4

BMC Veterinary Research

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Research article

Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA

Thomas Fett , Laurent LM Zecchinon , Etienne A Baise and Daniel JM Desmecht

Pathology Department, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium

author email corresponding author email

BMC Veterinary Research 2005, 1:4doi:10.1186/1746-6148-1-4


Published:	10 October 2005

Abstract

Background

Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response.

Results

The Capra hircus CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts. Despite some focal differences, it shares all the main characteristics of its known mammalian homologues.

Conclusion

Therefore, along with the caprine CD18-encoding cDNA, which has been available for a few months, the sequence data revealed here will allow the Capra hircus LFA-1 expression in vitro as a tool to explore the specificities of inflammation in the caprine species.