Table 2

Probiotic protocols from trials included in the updated meta-analysis

Study

Probiotic agent/s

Dose and duration


Kitajima 1997 [52]

Bifidobacterium breve

0.5 × 109 cfua once daily from first feed for 28 days.


Dani 2002 [53]

Lactobacillus rhamnosus GG

6 × 109 cfu once daily from first feed until discharge


Costalos 2003 [54]

Saccharomyces boulardii

109/kg twice daily from first feed for 30 days


Bin Nun 2005 [55]

Bifidobacterium infantis, Streptococcus thermophilus, Bifidobacterium bifidus

0.35 × 109 cfu B. infantis, 0.35 × 109 cfu S. thermophilus and 0.35 × 109 cfu B. bifidus once daily from first feed to 36 weeks corrected age


Lin 2005 [56]

Lactobacillus acidophilus, B. infantis

1004356 L. acidophilus and 1015697 B. infantis organisms twice daily from day 7 until discharge


Manzoni 2006 [57]

Lactobacillus casei

6 × 109 cfu once daily from 3 days to 6 weeks of age, or discharge from NICUb


Mohan 2006 [28]

Bifidobacterium lactis

1.6 × 109 cfu once daily from day 1 to day 3; 4.8 × 109 cfu once daily from day 4 to day 21


Stratiki 2007 [59]

B. lactis

Preterm formula: 1 × 107 cfu/g started within 48 hours to 30 days


Lin 2008[60]

B. bifidus, L. acidophilus

2 × 109 cfu daily for 6 weeks


Samanta 2009[61]

B. bifidus, B. lactis, B. infantis, L.s acidophilus

2.5 × 109 cfu daily until discharge


Rouge 2009 [62]

Bifidobacterium longum, Lactobacillus GG

1 × 108 cfu daily until discharge


aColony-forming units.

bNeonatal intensive-care unit.

Deshpande et al. BMC Medicine 2011 9:92   doi:10.1186/1741-7015-9-92

Open Data