Table 3

Multiple logistic regression to assess the associations of types of intervention, time before and after CONSORT and impact of journal with aspects of trial design, conduct and analysis

Drug versus non-drug

From 2001 versus before 2001

Per increase of 1 unit in impact factor


Reporting of between-group comparisons

2.39 (0.46 to 12.50) (0.30)

2.73 (0.63 to 11.90) (0.18)

1.19 (0.95 to 1.49) (0.14)

Primary outcome reported

8.15 (3.16 to 21.03) (< 0.001)

8.46 (3.18 to 22.49) (< 0.001)

1.06 (1.01 to 1.11) (0.010)

Primary outcome is only one measure

4.19 (1.68 to 10.46) (0.002)

5.81 (2.17 to 15.59) (< 0.001)

1.04 (1.01 to 1.08) (0.018)

No statistical comparison of baseline characteristics

2.48 (1.11 to 5.56) (0.027)

0.97 (0.46 to 2.03) (0.93)

1.0 2 (0.98 to 1.06) (0.30)

Reporting of handling of missing data

1.79 (0.74 to 4.32) (0.20)

2.47 (1.00 to 6.10) (0.049)

1.03 (1.00 to 1.06) (0.07)

Intention-to-treat analysis reported

2.88 (1.39 to 5.99) (0.005)

2.02 (0.99 to 4.15) (0.055)

1.03 (0.99 to 1.06) (0.11)

Reporting of P values and 95% CI (n)

1.85 (0.81 to 4.24) (0.15)

1.83 (0.79 to 4.22) (0.16)

1.07 (1.03 to 1.12) (< 0.001)


Data are odds ratios (95% CI) (P value)

Vollenweider et al. BMC Medicine 2011 9:73   doi:10.1186/1741-7015-9-73

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