Table 2

Diseases thought to be associated with GI barrier and GI microbiotaa

Location

Diseases for which the GI barrier plays a central role in pathogenesis

Diseases associated with an altered composition or function of the GI microbiota


Intestinal

Infectious diarrhoea [26,36]

Inflammatory bowel disease [130-132]

Coeliac disease [131]

Irritable bowel syndrome [133]

Inflammatory bowel disease [138,139]

Coeliac disease [140]

Irritable bowel syndrome [141,142]

Extraintestinal

Allergic diseases [20,134,135]

Autoimmune diseases and arthritis [17]

Obesity, fatty liver disease and nonalcoholic steatohepatitis (NASH) [35,136,137]

Systemic inflammatory response syndrome (SIRS) and sepsis in ICU patients [36,37]

Malnutrition [40]

Allergic diseases [143,144]

Arthritis [145]

Obesity [125]


aGI, gastrointestinal; ICU, intensive care unit.

Bischoff BMC Medicine 2011 9:24   doi:10.1186/1741-7015-9-24

Open Data