A sequential predictive algorithm integrating clinical and molecular biomarker findings to improve KD diagnosis. KD, blue; FC yellow. Left panel: clinical, blood testing, and urine testing cohorts were stratified and ordered according to their clinical scores. Patients with intermediate scores were further analyzed by 32 gene or 13 urine peptide based classifiers to discriminate KD and FC. Right panel: ROC analysis of all three-cohort patients with intermediate clinical scores analyzed by either clinical score (black), cell-specific, whole blood gene-based (red) and urine peptide-based (green) classifiers. Abbreviations: FC, febrile controls; KD, Kawasaki disease; ROC, receiver operating characteristic.
Ling et al. BMC Medicine 2011 9:130 doi:10.1186/1741-7015-9-130