Cell type-specific significance analysis of KD and FC whole blood microarray data. (Microarray analysis of peripheral whole blood, FC n = 16, KD n = 23, Testing data set 1). (A) SAM analysis revealing no differentially expressed genes in whole blood. (B) csSAM revealing differential expression in lymphocytes, but not in other cell types. Up: up-regulated in FC. Down: down-regulated in FC. Y axis: false discovery rate (FDR); X axis: number of differential genes at a given FDR. Microarray analysis of peripheral whole blood, FC n = 16, KD n = 23 (Testing data set 1). Abbreviations: FC, febrile controls; KD, Kawasaki disease; SAM, significance analysis of microarrays; scSAM, cell-type specific significance analysis of microarrays.
Ling et al. BMC Medicine 2011 9:130 doi:10.1186/1741-7015-9-130