Table 2

Multiple regression analysis with ADAS-Cog and E-ADL test as dependant variable (PP analysis, n = 61)

ADAS-Cog (12-month follow-up)

E-ADL test (12-month follow-up)


Independent variablea

Unstandardized β (95% CI)

t

P value

Unstandardized β (95% CI)

t

P value

Scoreb at baseline

0.82 (0.59-1.05)

7.14

< 0.001

0.80 (0.54-1.06)

6.23

< 0.001

Group (control = 0 vs. MAKS = 1)

-7.67 (-13.97--1.37)

-2.44

0.018

3.57 (0.72-6.42)

2.52

0.015

Age

0.13 (-0.47-0.73)

0.43

0.67

0.08 (-0.19-0.35)

0.58

0.57

Gender

1.02 (-6.90-8.94)

0.26

0.80

0.91 (-2.64-4.46)

0.51

0.61

Medication scorec

-0.38 (-2.14-1.39)

-0.43

0.67

-0.02 (-0.81-0.77)

-0.05

0.96

NOSGER, moodd

0.80 (-0.23-1.82)

1.56

0.13

-0.14 (-0.59-0.31)

-0.63

0.53

Participation scoree

-0.07 (-0.14--0.01)

-2.22

0.03

0.01 (-0.02-0.04)

0.82

0.42

Use of anti-dementia medicationf

-5.96 (-16.42-4.51)

-1.14

0.26

0.76 (-3.91-5.43)

0.33

0.74


P-values < 0.05 are in bold

Abbreviations: ADAS-Cog, Alzheimer's Disease Assessment Scale, subscale cognition; E-ADL test, Erlangen Test of Activities of Daily Living; PP, per protocol; NOSGER, Nurses' Observation Scale of Geriatric Patients.

aExcluded due to a lack of variance: educational attainment (93% with no more than elementary school education), excluded due to multicollinearity (r ≥ 0.50 with ADAS-Cog at baseline and/or E-ADL test at baseline): care level (0.76 with ADAS-Cog; 0.56 with the E-ADL test), Charlson comorbidity index (0.52 with ADAS-Cog); Mini Mental State Examination (0.71 with ADAS-Cog; 0.56 with the E-ADL test). bADAS-Cog at baseline if ADAS-Cog 12-month follow-up is dependent variable; E-ADL test at baseline if E-ADL test 12-month follow-up is dependent variable.

cSedating (< 0) or stimulating (> 0) effect or side effect of the prescribed medications. dNOSGER-mood subscale, which consists of five depression items rated on a scale of 1 (always) to 5 (never). The score ranges from 5 (no disturbance) to 25 (maximum possible degree of disturbance).

eSum score of all non-MAKS activities regularly offered by the nursing homes and in which patients participated on a voluntary basis. The scores were recorded by nursing staff each week throughout the observation period. Examples of such activities are singing groups or physical exercises to reduce the risk of falling. Each activity in which a patient participated was rated with one point. fUse of acetylcholinesterase (AChE) inhibitors or memantine.

Graessel et al. BMC Medicine 2011 9:129   doi:10.1186/1741-7015-9-129

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