A model of gene conversion between duplicons. Two homologous but non-allelic sequences are shown, with homology indicated by a common green color. After a double strand break in the original sequence, the template sequence is used to form a heteroduplex DNA structure with the original sequence during the process of repair. A possible repair outcome is shown, illustrating changes to both the template and original sequences far from the location of the break, as well as changes and deletion in the original sequence in the vicinity of the break.
Ross BMC Medicine 2011 9:12 doi:10.1186/1741-7015-9-12