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Open Access Research article

Atrazine-induced apoptosis of splenocytes in BALB/C mice

Xiaofeng Zhang, Mingqiu Wang, Shuying Gao, Rui Ren, Jing Zheng and Yang Zhang*

BMC Medicine 2011, 9:117  doi:10.1186/1741-7015-9-117

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Atrazine toxicity

Heikki Savolainen   (2011-11-26 16:45)  Dept. of Occup.Safety & Hlth., Tampere, Finland email

Dear Editor,

This interesting study opens new possible mechanisms for the elusive atrazine effects. In our own investigations, it was absorbed also through the skin with a very extensive metabolism in man and in a animal model (1). Thus, one wonders whether the findings are due to the parent compound or its metabolites. Apart from occasional cutaneous allergy cases, the exposure in our work was not associated with medium-term adverse effects. Therefore, the idea presented in the paper should be further examined.

1 Ikonen R, Kangas J, Savolainen H. Urinary atrazine metabolites as indicators for rat and human exposure to atrazine. Toxicol Lett 1988; 44: 109-112

Competing interests

None declared

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