Table 2

Risk of nasopharyngeal carcinoma associated with MNS16A by potential risk factors

Category

LLa,b

SL + SSa,b

OR (95% CI)c,d

Pe

Phomogeneityf


Age, years

0. 55

< 45

331/448

34/60

0. 78 (0. 50 to 1. 22)

0. 19

≥ 45

394/438

39/68

0. 65 (0. 43 to 0. 98)

0. 051

Gender

0. 24

Male

525/646

44/88

0. 61 (0. 42 to 0. 90)

0. 0090

Female

200/245

29/40

0. 90 (0. 54 to 1. 51)

0. 61

Tobacco use

0. 11

Nonsmoker

502/624

56/85

0. 82 (0. 57 to 1. 18)

0. 28

Smoker

223/267

17/43

0. 47 (0. 26 to 0. 85)

0. 0090

Smoking level (pack-years)

0. 34

< 24

635/787

65/109

0. 74 (0. 53 to 1. 03)

0. 071

≥ 24

90/104

8/19

0. 47 (0. 20 to 1. 13)

0. 080

Alcohol use

0. 39

Non-drinker

509/630

55/89

0. 76 (0. 53 to 1. 09)

0. 13

Drinker

217/261

18/39

0. 56 (0. 31 to 1. 02)

0. 032

Ethnicity

0. 77

Han

541/776

57/112

0. 72 (0. 52 to 1. 02)

0. 064

Non-Han

184/115

16/16

0. 67 (0. 30 to 1. 50)

0. 67

Family historyf

0. 70

Negative

678/862

71/127

0. 69 (0. 51 to 0. 95)

0. 022

Positive

47/29

2/1

1. 12 (0. 09 to 13. 26)

0. 88


aOwing to genotyping failure, the actual sample size was 798 and 1019 for the cases and controls, respectively.

bNumber of genotype in cases/number of genotype in controls. L allele, 302 or 333 bp; S allele, 243 or 272 bp.

cThe odds ratios (ORs) and P values were calculated by logistic regression with LL genotype as the reference group and adjusted for age, gender, tobacco and alcohol status, smoking level, ethnicity and family history where appropriate within the strata.

dConfidence interval

eFor difference in ORs within each stratum.

fFirst-degree relatives

Zhang et al. BMC Medicine 2011 9:106   doi:10.1186/1741-7015-9-106

Open Data