Table 3

Characteristics of included trials: Trials on various other conditionsa

Trial

Clinical problem

Sample size (% dropout)

Concealment

Outcome used for meta-analysis

Intervention details

Standard basic care in all groups


Allen et al. [33]

Depression

38

(11%)

Unclear

Hamilton Rating Scale for Depression after 8 weeks

N:12

D:n.i.

T:8w

Ac:A CA

S:I A 2

Probably no treatment at all

Allen et al. [34]

Depression

157

(13%)

Unclear

Hamilton Rating Scale for Depression after 8 weeks (PMOM)

N:12

D:20

T:8w

Ac:A CA

S:I A 2

Probably no treatment at all

Asher et al. [35]

Induction of labor

89

(0)

Adequate

PMOM: Time to delivery

N:7

D:30

T:2w

Ac:C CA

S:I A 1

Routine prenatal care

Aune et al. [36]

Recurrent urinary tract infections

67

(unclear)

Unclear

Patients without infection

N:8

D:20

T:4w

Ac:A CA

S:I C 1

No treatment

Avis et al. [37]

Menopausal hot flashes

56

(0)

Adequateb

Reduction in hot flash frequencyb

N:16

D:30

T:8w

Ac:B CA

S:B A 2

Continuation of nondrug treatment used before trial

Bullock et al. [40]

Addiction (cocaine abuse)

236

(59%)

Unclear

Addiction severity scale drug use in week 8

N:28

D:45

T:8w

Ac:C EarA

S:I C 2

Eden psychosocial programmingd

Freire et al. [47]

Moderate obstructive sleep apnea syndrome

36

(28%)

Unclear

Apnea-hypopnea index after 12 weeks

N:10

D:30

T:10w

Ac:C CA

S:I C 1

Offer to receive sleep hygiene counseling

Lembob et al. [54]

Irritable bowel syndrome (IBS)

231

(8%)

Adequate

PMOM: IBS Global Improvement Scale week 3

N:6

D:20

T:3w

Ac:B CA

S:II B 1

Continuation of drugs and diet used before trial

Medici et al. [57]

Stable chronic asthma

66

(0)

Unclear

PMOM: Peak expiratory flow variability baseline to 4 months

N:16

D:20

T:8w

Ac:C CA

S:I C 1

Asthma drugs adapted if necessaryd

Rampes et al. [60]

Addiction (alcohol abuse)

59

(54%)

Adequatec

PMOM: VAS craving for alcohol after 8 weeks

N: 6

D: 30

T: 6w

Ac:C EarA

S:I C 2

Individual counseling and group therapyd

Röschke et al. [61]

Depression

70

(unclear)

Unclear

Responder according to Global Assessment Scale (GAS)

N: 12

D: 30

T: 4w

Ac:C CA

S:I C 1

Mianserin 90 to 120 mg/day in all groupsd

Smith et al. [63]

Nausea and vomiting during pregnancy

445

(25%)

Adequate

Rhodes Index of Nausea after 4 weeks

N: 5

D: 20

T: 4w

Ac:A CA

S:I C 1

Pretrial treatment continued; lifestyle recommendations

Tremeau et al. [65]

Cervical maturation 37th to 38th pregnancy week

98

(18%)

Unclear

PMOM: Bishop score baseline to 10 days

N: 3

D: 20

T: 1w

Ac:C CA

S:I C 1

None

Wang et al. [66]

Low-back and pelvic pain during pregnancy

159

(4%)

Adequatec

PMOM: VAS pain change after 1 weekc

N: 1

D:c

T: 1w

Ac:C EA

S:I C 2

Acetaminophen and other self-care if needed

Worner et al. [68]

Addiction (alcohol abuse)

56

(95%)

Unclear

Patients with either relapse or inpatient detoxification

N: n.i.

D: 30

T: 12w

Ac:C CA

S:II C 1

Counseling and group therapyd


aSee Table 1 footnotes for definitions of abbreviations bTwo sham groups with different context. cAdditional information received from author. dClassified as intense cointervention likely to influence the outcome.

n.i. = no information reported

Linde et al. BMC Medicine 2010 8:75   doi:10.1186/1741-7015-8-75

Open Data