Table 3 

Effect of intervention on primary and secondary endpoints 

Outcomes 
3Day Routine Change Group (n = 177) 
Clinically Indicated Change Group (n = 185) 
RR (95% CI), P Value 


Primary: 

IVD complications per patient, n (%) 
64 (36%) 
76 (41%) 
RR 1.14 (0.88, 1.47), p = 0.39 
IVD complications per 1000 IVD days 
66.0 (95% CI 49.8, 82.1) 
67.8 (95% CI 52.6, 83.1) 
HR 1.03 (0.74, 1.43), p = 0.86 
Secondary: 

Phlebitis, n (%) 
12 (7%) 
18 (10%) 
RR 1.44 (0.71, 2.89), p = 0.34 
Infiltration, n (%) 
53 (30%) 
61 (33%) 
RR 1.10 (0.81, 1.49), p = 0.57 
Occlusion, n (%) 
5 (3%) 
4 (2%) 
RR 0.77 (0.21, 2.80), p = 0.75 
Accidental removal, n (%) 
11 (6%) 
16 (9%) 
RR 1.39 (0.66, 2.92), p = 0.43 
Local infection 
0 
0 
 
IVDrelated BSI, n (%) 
0 
0 
 
IVD costs per patient, AUD$ mean (SD) 
$55.42 ($35.26) 
$43.35 ($26.78) 
Mean difference $12.07 (95%CI $5.57, $18.56), p < 0.001 


Rickard et al. BMC Medicine 2010 8:53 doi:10.1186/17417015853 