Figure 4.

Time of going to bed during the treatment period. MMRM-predicted mean values (mean + standard error of mean) for time going to bed (hours relative to midnight) from the sleep diary at baseline and weeks 3-29 of the double blind treatment periods, Intention to Treat (ITT) 65-80 population. Asterisks denote significant difference between prolonged release melatonin and placebo groups (*P < 0.05 ** P < 0.01). Numbers of patients analysed in each treatment time point are depicted.