Table 3 |
|||||
|
Tests of association between SNPs and CAD using FBAT. |
|||||
|
Chromosome |
Gene |
SNP |
RS number |
MAF |
P-value * |
|
|
|||||
|
1p32-p31 |
VCAM1 |
T707C |
1041163 |
0.16 |
0.39 |
|
|
|||||
|
1q21-24 |
SELP |
G40A |
6131 |
0.18 |
0.84 |
|
|
|||||
|
G75271T |
6133 |
0.14 |
0.67 |
||
|
|
|||||
|
1q22-q25 |
SELE |
A153C |
5361 |
0.11 |
0.33 |
|
|
|||||
|
1q31-32 |
IL10 |
C8700A |
1800872 |
0.24 |
0.29 |
|
|
|||||
|
2q12-q21 |
IL1α |
C549T |
1800587 |
0.31 |
0.08 |
|
|
|||||
|
2q14 |
IL1β |
C4336T |
1143634 |
0.26 |
0.58 |
|
|
|||||
|
C1423T |
16944 |
0.34 |
0.49 |
||
|
|
|||||
|
2q33 |
CTLA4 |
C875T |
5742909 |
0.10 |
0.34 |
|
|
|||||
|
2q33 |
CTLA4 |
A1241G |
231775 |
0.40 |
0.68 |
|
|
|||||
|
3p21 |
CCR2 |
G46295A |
1799864 |
0.08 |
0.88 |
|
|
|||||
|
3p21 |
CCR5 |
Wt/del 580-611 |
333 |
0.14 |
0.72 |
|
|
|||||
|
G59029A |
1799987 |
0.44 |
0.33 |
||
|
|
|||||
|
3p21.3 |
CCR3 |
C320T |
5742906 |
0.01 |
- † |
|
|
|||||
|
3p26-p24 |
IL5RA |
G482A |
2290608 |
0.28 |
0.10 |
|
|
|||||
|
4q12-q13 |
GC |
G35706T |
7041 |
0.44 |
0.50 |
|
|
|||||
|
GC |
C35717A |
4588 |
0.29 |
0.21 |
|
|
|
|||||
|
5q22-32 |
CD14 |
C2232T |
2569190 |
0.47 |
0.63 |
|
|
|||||
|
5q23-q31 |
IL4 |
C582T |
2243250 |
0.14 |
0.66 |
|
|
|||||
|
5q31 |
IL13 |
C4045T |
1295686 |
0.20 |
0.78 |
|
|
|||||
|
5q31 |
TCF7 |
C883A |
5742913 |
0.12 |
0.35 |
|
|
|||||
|
5q31.1 |
TCF7 |
A383T |
25882 |
0.14 |
0.49 |
|
|
|||||
|
5q31.1 |
CSF2 |
T2600C |
244656 |
0.22 |
0.16 |
|
|
|||||
|
5q31-q32 |
ADRB2 |
A1633G |
1042713 |
0.37 |
0.91 |
|
|
|||||
|
C1666G |
1042714 |
0.42 |
0.37 |
||
|
|
|||||
|
C2078T |
1800888 |
0.02 |
- † |
||
|
|
|||||
|
5q31-q35 |
IL9 |
C4244T |
2069885 |
0.13 |
0.01 (T) |
|
|
|||||
|
5q35 |
LTC4S |
A620C |
730012 |
0.31 |
0.22 |
|
|
|||||
|
6p21.3 |
LTA |
A1069G |
909253 |
0.39 |
0.60 |
|
|
|||||
|
TNF |
G3787A |
1800629 |
0.21 |
0.34 |
|
|
|
|||||
|
G3857A |
361525 |
0.07 |
0.99 |
||
|
|
|||||
|
7p21-p15 |
IL6 |
G589C |
1800796 |
0.06 |
0.33 |
|
|
|||||
|
G987C |
1800795 |
0.43 |
0.38 |
||
|
|
|||||
|
7q35-q36 |
NOS3 |
A498G |
1800779 |
0.40 |
0.05 (G) |
|
|
|||||
|
G7002T |
1799983 |
0.36 |
0.67 |
||
|
|
|||||
|
9q32-q34 |
C5 |
A2416G |
17611 |
0.44 |
0.04 (G) |
|
|
|||||
|
10q11.1 |
SDF1 |
G880A |
1801157 |
0.20 |
0.84 |
|
|
|||||
|
11q11-qter |
UGB |
G587A |
3741240 |
0.36 |
0.65 |
|
|
|||||
|
11q13 |
FCERB1 |
A7297G |
569108 |
0.03 |
0.48 |
|
|
|||||
|
12q13.1 |
VDR |
T12022C |
2228570 |
0.40 |
0.77 |
|
|
|||||
|
G45082A |
1544410 |
0.42 |
0.61 |
||
|
|
|||||
|
16p11.2-p12.1 |
IL4R |
A398G |
1805010 |
0.46 |
0.56 |
|
|
|||||
|
T1682C |
1805015 |
0.20 |
0.01 (C) |
||
|
|
|||||
|
A1902G |
1801275 |
0.25 |
0.04 (G) |
||
|
|
|||||
|
17q11.2-q12 |
NOS2A |
C231T |
1137933 |
0.23 |
0.98 |
|
|
|||||
|
17q21.1-q21.2 |
SCYA11 |
G361A |
3744508 |
0.19 |
0.04 (G) |
|
|
|||||
|
G1169A |
4795895 |
0.20 |
0.47 |
||
|
|
|||||
|
19q13.1 |
TGFB1 |
C629T |
1800469 |
0.27 |
- ‡ |
|
|
|||||
|
19p13.2 |
ICAM1 |
A120T |
5491 |
0.001 |
- ‡ |
|
|
|||||
|
G657A |
1799969 |
0.12 |
0.43 |
||
|
|
|||||
|
19p13.3-p13.2 |
C3 |
C364G |
2230199 |
0.24 |
0.39 |
|
|
|||||
|
* In parenthesis after the P-value: the allele associated with an increased disease risk. † Number of informative families below 50. ‡ Not in Hardy-Weinberg equilibrium. MAF, minor allele frequency; SNP, single nucleotide polymorphism; CAD, coronary artery disease. |
|||||
|
Brown et al. BMC Medicine 2010 8:5 doi:10.1186/1741-7015-8-5 |
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