Open Access Research article

An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

Benjamin D Brown1, Jérémie Nsengimana2, Jennifer H Barrett2, Richard A Lawrence1, Lori Steiner3, Suzanne Cheng3, D Timothy Bishop2, Nilesh J Samani4, Stephen G Ball1, Anthony J Balmforth1 and Alistair S Hall1*

Author Affiliations

1 Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, UK

2 Leeds Institute of Molecular Medicine (LIMM), University of Leeds, UK

3 Roche Molecular Systems, Pleasanton, California, USA

4 Department of Cardiovascular Sciences, University of Leicester, UK

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BMC Medicine 2010, 8:5  doi:10.1186/1741-7015-8-5

Published: 13 January 2010

Additional files

Additional file 1:

Details on the recruitment of study participants.

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Additional file 2:

List of the polymorphisms analysed in this study (Table S1), with all their characteristics (chromosome region, long and short gene name, common SNP name, rs number, amino acid change).

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Additional file 3:

Details on the statistical methods in data validation and genetic association testing.

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