Table 1

Details of included studies

Study name

Study characteristics

Quality assessment


Tx

Country

Diag

Outcome

No. sessions

Type of data

FU (weeks)

Total N

Rand.

AC

ITT

% attrition (Intv)

% attrition (Ctl)


Barrett 2001 [67]

PST

USA

Dep - minor or dys

HDRS < 7

6

D

11

161

WC

WC

Y

18

16

Boot 1994 [58]

COU

UK

Mixed Anx and Dep

GHQ

6

C

6

192

AA

U

N

46

40

Brodaty 1983 [66]

PP

AUS

Mixed Anx and Dep

GHQ

8

C

8

78

AA

U

N

65

26

Catalan 1991 [68]

PST

UK

Mixed Anx and Dep

PSE

4

C

11

47

AA

U

N

0

0

Dowrick 2000 [69]

PST

EU

Dep - MDD or dys

BDI

6

C

26

317

AA

WC

Y

23

26

Earll 1982 [46]

CBT

UK

Mixed Anx and Dep

DSSI/sAD *

7.7

D

32

50

AA

U

N

16**

Friedli 1997 [59]

COU

UK

Mixed Anx and Dep

BDI

9

C

12

136

AA

AA

Y

16

23

Harvey 1998 [60]

COU

UK

Mixed Anx and Dep

HADS

6

C

16

162

AA

U

Y

31

25

Hemmings 1997 [61]

COU

UK

Mixed Anx and Dep

MHSI

5.7

C

16

188

AA

U

N

16

23

Holden 1989 [62]

COU

UK

Dep - MDD

RDC

8

D

12

50

AA

U

N

0

0

Kendrick 2005 [70]

PST

UK

Mixed Anx and Dep

CIS-R

6

C

26

168

WC

WC

Y

20 †

31†

Lang 2006 [71]

PST

USA

Mixed Anx and Dep

BSI-D

4

C

12

62

AA

U

Y

34

17

Lindsay 1987 [47]

CBT

UK

Anx - GAD

GHQ-28

8

C

4

20

AA

U

N

0

0

Liu 2007 [72]

PST

TA

Mixed Anx and Dep

CIS-R

2.27

C

16

169

WC

AA

Y

25

22

Lynch 1997 [73]

PST

USA

Dep - minor

HDRS

6

C

7

29

AA

U

N

27

7

Lynch 2004 [74]

PST

USA

Dep - minor

HDRS

6

C

6

36

AA

U

N

50

28

Marks 1985 [48]

CBT

UK

Anx - phobic

PS

6

C

26

92

AA

U

N

37

20

Mynors-Wallis 1995 [75]

PST

UK

Dep - MDD

HDRS

6

C

12

55

AA

U

Y

0

0

Mynors-Wallis 1997 [76]

PST

UK

Mixed Anx and Dep

CIS

4.5

C

26

70

AA

AA

N

20

13

Power 1989 [49]

CBT

UK

Anx - GAD

HAM-A

4

C

6

21

AA

U

Y

0

0

Power 1990 [51]

CBT

UK

Anx - GAD

CGI = 1

7

D

10

79

AA

U

N

0

0

Power 2000 [50]

CBT

UK

Anx - panic

HAM-A

6

C

12

72

AA

U

N

16

17

Prendegast 2001 [52]

CBT

AUS

Dep - mixed

EPDS < 10

6

D

26

37

AA

U

N

0

0

Robson 1984 [53]

CBT

UK

Mixed Anx and Dep

PS

3.7

C

14

429

AA

U

N

0 ††

0 ††

Schreuders 2007 [77]

PST

NL

Mixed Anx and Dep

HADS

6

C

12

175

AA

WC

N

30

22

Scott 1992 [54]

CBT

UK

Dep - MDD

HDRS

9.8

C

16

60

AA

AA

Y

3

3

Scott 1997 [55]

CBT

UK

Dep - MDD

HDRS

6

C

7

48

AA

U

N

25

33

Sharp 1996 [56]

CBT

UK

Anx - panic

HAM-A ‡

7

D

13

154

AA

U

Y

21§

24§

Sharp 2004 [57]

CBT

UK

Anx - panic

HAM-A

8

C

12

59

AA

U

Y

16

14

Simpson 2003 [63]

COU

UK

Dep - mixed

BDI

5

C

26

145

AA

U

Y

11

10

Van Schaik 2006 [65]

IPT

NL

Dep - MDD

MADRS

8

C

26

143

WC

WC

Y

16

16

Ward 2000 [27]

CBT

UK

Dep - mixed

BDI

5

C

16

197

AA

U

Y

11

8

COU

6.4

8

Wickberg 1996 [64]

COU

SW

Dep - mixed

MADRS ¶

6

D

7

45

AA

U

N

0

0

Williams 2000 [78]

PST

USA

Dep - minor or dys

HDRS < 7

6

D

11

278

WC

AA

Y

18§

15§


* Patients were categorized as not 'personally ill' by study authors.

** Number randomized to each group not reported by study authors.

We used missing data that were imputed from a regression analysis that took account of the baseline information for each participant with missing data rather than from last observation carried forward because of differential attrition between study groups.

†† Attrition not reported by study authors; therefore we assumed there was no missing data.

Study authors defined response as a clinically significant change.

§ For the purposes of the meta-analysis, participants with missing data were assumed to have had a poor outcome.

Study authors defined response as a substantial improvement.

AA, adequately addressed; AC, allocation concealment; AUS, Australia; Anx, anxiety; BDI, Beck Depression Inventory; BSI-D, Brief Symptom Inventory - Depression scale; C, continuous; CBT, cognitive behavioural therapy; CES-D, Center for Epidemiologic Studies Depression Scale; CGI, Clinical Global Impression; CIS-R, Clinical Interview Schedule - Revised; COU, Counselling; Ctl, control; D, dichotomous; Dep, depression; Dep - mixed, mixed depressive diagnoses including minor depression; Diag, diagnosis; DSSI/sAD, Delusions-Symptoms-States Inventory/states of Anxiety and Depression; dys, dysthymia; EPDS, Edinburgh Postnatal Depression Scale; EU, European countries; GHQ, General Health Questionnaire; HADS, Hospital Anxiety and Depression Scale; HAM-A, Hamilton Anxiety Rating Scale; HDRS, Hamilton Depression Rating Scale; Intv, intervention; IPT, Interpersonal psychotherapy; ITT, intention-to-treat analysis; MADRS, Montgomery-Åsberg Depression Rating Scale; MDD, major depressive disorder; MHSI, Mental Health Symptom index;; Mixed Anx and Dep, mixed anxiety and depression diagnoses; N, number randomized; NL, Netherlands; PP, Psychodynamic psychotherapy; PS, psychiatric symptoms; PSE, Present State Examination; PST, problem solving therapy; Rand., randomization; RDC, Research Diagnostic Criteria; SW, Sweden; TA, Taiwan; Tx, treatment; U, unclear; WC, well covered; Y, yes.

Cape et al. BMC Medicine 2010 8:38   doi:10.1186/1741-7015-8-38

Open Data