BMC Medicine

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A compact VEGF signature associated with distant metastases and poor outcomes

Zhiyuan Hu1,2, Cheng Fan1, Chad Livasy1,3, Xiaping He1,2, Daniel S Oh1,2, Matthew G Ewend1,4, Lisa A Carey1,4, Subbaya Subramanian5, Robert West5, Francis Ikpatt6, Olufunmilayo I Olopade6, Matt van de Rijn5 and Charles M Perou1,2,3*

Author Affiliations

1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

2 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

3 Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

4 Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

5 Department of Pathology, Stanford University Medical Center, Stanford, CA 94035, USA

6 Section of Hematology/Oncology, Department of Medicine, Committees on Genetics and Cancer Biology, University of Chicago, South Maryland Avenue, Chicago, IL 60637-1463, USA

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BMC Medicine 2009, 7:9 doi:10.1186/1741-7015-7-9

Published: 16 March 2009

Additional files

Additional file 1:

Supplementary table. Summary of GEO submission of 202 microarrays used in this paper and clinical data of the patients in this study.

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Additional file 2:

Figure S1. The complete cluster diagram of all 146 patients using the 1195 gene. MetScore-associated gene list.

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Additional file 3:

Figure S2. Univariate Kaplan-Meier survival plots for patients stratified using the VEGF profile based upon rank order expression on the A-B) UNC training data set, C-D) NKI test data set, E-F) Bhattacharjee et al [29] lung carcinoma data set, and G-H) Nutt et al [30] glioblastoma data set.

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