Table 2 |
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Enzymes co-regulated at the gene and protein level by Signal Transducer and Activator of Transcription 1 (STAT1) |
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Pathway |
Gene Symbol |
Description |
Function |
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GG |
ALDH1A1 |
Aldehyde dehydrogenase 1 family, member A1 |
Oxidation of acetaldehyde to acetate |
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GG |
ALDH2 |
Aldehyde dehydrogenase 2 family (mitochondrial) |
Oxidation of acetaldehyde to acetate |
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GG |
ALDOA |
Aldolase A, fructose-bisphosphate |
Cleavage of fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate |
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GG |
ENO1 |
Enolase 1, (alpha) |
Dehydration of 2-phosphoglycerate to phosphoenolpyruvate |
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GG |
ENO2 |
Enolase 2 (gamma, neuronal) |
Dehydration of 2-phosphoglycerate to phosphoenolpyruvate |
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GG |
ENO3 |
Enolase 3 (beta, muscle) |
Dehydration of 2-phosphoglycerate to phosphoenolpyruvate |
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GG |
GAPDH |
Glyceraldehyde-3-phosphate dehydrogenase |
Oxidation and phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate with reduction of NAD+ to NADH |
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GG |
GPI |
Glucose phosphate isomerase |
Conversion of glucose 6-phosphate to fructose 6-phosphate |
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GG |
LDHA |
Lactate dehydrogenase A |
Reduction of pyruvate to lactate with oxidation of NADH to NAD+ |
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GG |
LDHAL6B |
Lactate dehydrogenase A-like 6B |
Reduction of pyruvate to lactate with oxidation of NADH to NAD+ |
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GG |
LDHB |
Lactate dehydrogenase B |
Reduction of pyruvate to lactate with oxidation of NADH to NAD+ |
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GG |
PGAM1 |
Phosphoglycerate mutase 1 (brain) |
Conversion of 3-phosphoglycerate to 2-phosphoglycerate |
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GG |
PGK1 |
Phosphoglycerate kinase 1 |
Phosphoryl transfer from 1,3-bisphosphoglycerate to ADP with formation of 3-phosphoglycerate and ATP |
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GG |
PGM1 |
Phosphoglucomutase 1 |
Interconversion of glucose 1-phosphate and glucose 6-phosphate |
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GG |
PKM2 |
Pyruvate kinase type 2, muscle |
Phosphoryl transfer from phosphoenolpyruvate to ADP with formation of pyruvate and ATP |
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GG |
TPI1 |
Triosephosphate isomerase 1 |
Interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate |
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OP |
ATP5A1 |
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
Synthesis of ATP from ADP and inorganic phosphate |
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OP |
ATP5O |
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
Synthesis of ATP from ADP and inorganic phosphate |
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OP |
ATP5B |
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide |
Synthesis of ATP from ADP and inorganic phosphate |
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OP |
COX4I1 |
Cytochrome c oxidase subunit IV isoform 1 |
Oxidation of cytochrome C with reduction of O2 to H2O |
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OP/CC |
SDHA |
Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
Oxidation of succinate to fumarate with reduction of FAD+ to FADH2 |
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CC |
MDH2 |
Malate dehydrogenase 2, NAD (mitochondrial) |
Oxidation of malate to oxaloacetate with reduction of NAD+ to NADH |
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GG, glycolysis/gluconeogenesis; OP, oxidative phosphorylation; CC, citrate cycle |
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Pitroda et al. BMC Medicine 2009 7:68 doi:10.1186/1741-7015-7-68 |
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