Table 7

Post-discharge outcomes for the three main bacterial pathogens, by study

Reference

Bacteria

Country

No. cases discharged

PD CFR

Average follow-up time, months (or range)

Total no. assessed for sequelae

HL (%)

VL (%)

CD (%)

SLD (%)

BP (%)

MI (%)

SZ (%)

Any neuropsychological sequelae (%)


[41]

Spn

Egypt

77

0%

3

77

5%

0%

0%

0%

5%

[48]

Spn

Cameroon

14

34

21%

6%

9%

9%

3%

6%a

9%

41%

[22]

Spn

The Gambia

70

23%

(11 to 90)

31

48%

23%

32%

48%b

10%

58%

[41]

Hib

Egypt

39

0%

3

39

0%

0%

0%

0%

0%

[36]

Hib

The Gambia

58

16%

8

48

13%

[22]

Hib

The Gambia

90

14%

(11 to 90)

42

21%

2%

14%

12%b

26%

38%

[50]

Nm

Tunisia

55

60

55

9%

[41]

Nm

Egypt

251

0%

3

251

2%

0%

0%

1%a

3%


This table shows the findings of studies with post-discharge follow-up of at least 25 children following confirmed bacterial meningitis (CBM) caused by 1 of the 3 main bacterial pathogens. The number of cases discharged was calculated based on the number of CBM cases included in the study minus the number of children reported who died in hospital. Post-discharge case fatality ratio (CFR) was calculated as the number of deaths after discharge divided by the number of cases with known follow-up; the denominator does not include cases lost to follow-up.

aParalysis; bgross motor impairment.

BP = behavioural problem; CD = cognitive delay; Hib = Haemophilus influenzae type b; HL = hearing loss; MI = motor impairment; Nm = Neisseria meningitidis; Spn = Streptococcus pneumoniae; SLD = speech or language disorder; SZ = seizures; VL = vision loss.

Ramakrishnan et al. BMC Medicine 2009 7:47   doi:10.1186/1741-7015-7-47

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