Surgery-free survival (restricted to the 25 surgeries clinically or pathologically judged as due to fenfluramine exposure). Comparison is made between those with baseline mild or greater aortic regurgitation or moderate or greater mitral regurgitation (FDA+) versus those with less or no regurgitation (FDA-). 23 of the 25 surgeries occurred in those who were FDA+ at baseline. The difference in surgery-free survival between the groups was highly significant (p < 0.0001 by log-rank test).
Dahl et al. BMC Medicine 2008 6:34 doi:10.1186/1741-7015-6-34