The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study

Jeanne C Latourelle¹ , Mei Sun² , Mark F Lew³ , Oksana Suchowersky⁴ , Christine Klein⁵ , Lawrence I Golbe⁶ , Margery H Mark⁶ , John H Growdon⁷ , G Frederick Wooten⁸ , Ray L Watts⁹ , Mark Guttman¹⁰ , Brad A Racette¹¹ , Joel S Perlmutter¹¹ , Anwar Ahmed¹² , Holly A Shill¹³ , Carlos Singer¹⁴ , Stefano Goldwurm¹⁵ , Gianni Pezzoli¹⁵ , Michela Zini¹⁵ , Marie H Saint-Hilaire¹ , Audrey E Hendricks^1,16 , Sally Williamson¹ , Michael W Nagle¹ , Jemma B Wilk¹ , Tiffany Massood¹ , Karen W Huskey¹ , Jason M Laramie¹ , Anita L DeStefano^1,16 , Kenneth B Baker¹⁷ , Ilia Itin¹⁷ , Irene Litvan¹⁸ , Garth Nicholson¹⁹ , Alastair Corbett¹⁹ , Martha Nance²⁰ , Edward Drasby²¹ , Stuart Isaacson²² , David J Burn²³ , Patrick F Chinnery²⁴ , Peter P Pramstaller²⁵ , Jomana Al-hinti²⁶ , Anette T Moller²⁷ , Karen Ostergaard²⁷ , Scott J Sherman²⁸ , Richard Roxburgh²⁹ , Barry Snow²⁹ , John T Slevin³⁰ , Franca Cambi³⁰ , James F Gusella² and Richard H Myers¹

¹  Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA

²  Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA

³  Department of Neurology, University of Southern California, Los Angeles, CA, USA

⁴  Departments of Clinical Neurosciences and Medical Genetics, University of Calgary, Calgary, Alberta, Canada

⁵  Department of Neurology, Medical University of Lübeck, Lübeck, Germany

⁶  Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, USA

⁷  Department of Neurology, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA

⁸  Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA

⁹  Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA

¹⁰  Department of Medicine, University of Toronto, Toronto, Canada

¹¹  Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA

¹²  Barrow Neurological Institute, Phoenix, AZ, USA

¹³  Sun Health Research Institute, Sun City, AZ, USA

¹⁴  Department of Neurology, University of Miami, Miami, FL, USA

¹⁵  Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy

¹⁶  Department of Biostatistics, Boston University School of Medicine, Boston University, Boston, MA, USA

¹⁷  Departments of Neurology and Neuroscience, Cleveland Clinic Foundation, Cleveland, OH, USA

¹⁸  Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA

¹⁹  Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital, Sydney, Australia

²⁰  Struthers Parkinson's Center, Park Nicollet Clinic, Golden Valley, MN, USA

²¹  Port City Neurology, Scarborough, ME, USA

²²  Parkinson's Disease and Movement Disorder Center of Boca Raton, Boca Raton, FL, USA

²³  Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK

²⁴  Regional Neurosciences Centre, Newcastle University, Newcastle upon Tyne, UK

²⁵  Department of Neurology, General Regional Hospital Bolzano, Bolzano, Italy

²⁶  Department of Neurology, University of Arkansas for Medical Sciences, AR, USA

²⁷  Department of Neurology, Aarhus University Hospital, Aarhus, Denmark

²⁸  Department of Neurology, University of Arizona, Tucson, AZ, USA

²⁹  Department of Neurology, Auckland City Hospital, Auckland, New Zealand

³⁰  Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA