Table 4

Top SNPs ranked by univariate analysis for trial E9486.

Rank

rs ID

pval

Gene Sym

Gene Name

SNP Function


1.0

rs10018625

0.001536

TAG ERROR

TAG ERROR

unknown, TAG ERROR

2.0

rs1047643

0.001603

FDFT1

Farnesyl-diphosphate farnesyltransferase 1

coding-synon

3.0

rs20541

0.001644

IL13

Interleukin 13

coding-nonsynon

4.0

rs2108622

0.0020374

CYP4F2

Cytochrom P450, family 4, subfamily F, polypeptide 2

coding-nonsynon

5.0

rs3759259

0.002362

STYK1

Protein kinase STYK1

coding-nonsynon

6.0

rs1801133

0.003251

MTHFR

5, 10-methylenetetrahydrofolate reductase (NADPH)

coding-nonsynon

7.0

rs2069456

0.003375

CDK5

Cyclin-dependent kinase 5

intron

8.0

rs1131532

0.005650

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

coding-synon

9.0

rs882709

0.005965

SETX

senataxin

coding-nonsynon

10.0

rs4646421

0.007847

CYP1A1

Cytochrome P450, family 1, subfamily A, polypeptide 1

intron

11.0

rs1799969

0.008221

ICAM1

Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

coding-nonsynon

12.0

rs3822430

0.009157

SRD5A1

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

coding-synon

13.0

rs7903344

0.009471

CHUK

Conserved helix-loop-helix ubiquitous kinase

coding-nonsynon

14.0

rs13926

0.011531

TRAP1

TNF receptor-associated protein 1

coding-nonsynon

15.0

rs3172469

0.012006

BCL6

B-cell CCL/lymphoma 6 (zinc finger protein 51)

intron

16.0

rs215101

0.012028

ABCC1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

intron, TagSNP:ABCC1

17.0

rs2227564

0.012246

PLAU

Plasminogen activator, urokinase

coding-nonsynon

18.0

rs3096057

0.012484

CSF1

Colony stimulating factor 1 (macrophage)

Promoter

19.0

rs6474491

0.013935

STAR

Steriodogenic acute regulator

Promoter

20.0

rs2066471

0.015231

MTHRF

5, 10-methlyenetetrahydrofolate reductase (NADPH)

intron


Van Ness et al. BMC Medicine 2008 6:26   doi:10.1186/1741-7015-6-26

Open Data