Table 3

Top SNPs ranked by univariate analysis for trial S9321

Rank

rs ID

pval

Gene Sym

Gene Name

SNP Function


1.0

rs2066534

0.001280

FMO3

Flavin containing monooxygenase 3

intron

2.0

rs696217

0.001877

GHRL

Ghrelin precursor

coding-nonsynon

3.0

rs1043424

0.002404

PINK1

PTEN induced putative Kinase 1

coding-nonsynon

4.0

rs174680

0.003361

COMT

Catechol-O-methyltransferase

intron

5.0

rs316132

0.003443

GSTA4

Glutathione S-transferase A4

intron, TagSNP:GSTA4

6.0

rs1884725

0.004564

XDH

Xanthine dehydrogenase

coding-nonsynon

7.0

rs2069391

0.004830

CDK2

Cyclin-dependent kinase 2

8.0

rs4148217

0.006167

ABCG8

ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)

coding-nonsynon

9.0

rs11700112

0.007423

PAK7

P21 (CDKN1A)-activated kinase 7

coding-nonsynon

10.0

rs1052536

0.007643

LIG3

Ligase III, DNA, ATP-dependent

untranslated

11.0

rs2618346

0.008033

DUSP1

Dual specificity phosphatase 1

3' UTR

12.0

rs9282564

0.008239

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

coding-nonsynon

13.0

rs53683

0.008429

GHRL

Ghrelin precursor

intron

14.0

rs2227314

0.009244

IL12A

Interleukin 12A (natural killer cell stimulatory factor 1, cytotixic lymphocyte maturation factor 1, p35)

intron

15.0

rs1801243

0.010739

ATP7B

ATPase, Cu++ transporting, beta polypeptide (Wilson disease)

coding-nonsynon

16.0

rs2953983

0.010792

POLB

Polymerase (DNA directed), beta

intron

17.0

rs4148946

0.011822

CHST3

Sarbohydrate (chondroitin 6) sulfotransferase 3

untranslated

18.0

rs7185307

0.011895

TNFRSF17

Tumor necrosis factor receptor superfamily, member 17

locus, TagSNP:TNFRSG17(BCMA)

19.0

rs699473

0.012077

SOD3

Superoxide dismutase 2, extracellular

intron

20.0

rs880324

0.012969

NFATC2

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

intron


Van Ness et al. BMC Medicine 2008 6:26   doi:10.1186/1741-7015-6-26

Open Data